Directed evolution of GFP with non-natural amino acids identifies residues for augmenting and photoswitching fluorescence† †Electronic supplementary information (ESI) available: Detailed experimental methods, supplementary Fig. 1 to 11 and supplementary Tables 1–3. See DOI: 10.1039/c4sc02827a Click here for additional data file.

Functional modulation and directed assembly of an enzyme through designed non-natural post-translation modification† †Electronic supplementary information (ESI) available: Detailed experimental methods, supplementary Fig. 1 to 11 and supplementary Tables 1 to 3. See DOI: 10.1039/c4sc03900a Click here for additional data file. Click here for additional data file.

Post-translational modification (PTM) modulates and supplements protein functionality. In nature this high precision event requires specific motifs and/or associated modification machinery. To overcome the inherent complexity that hinders PTM's wider use, we have utilized a non-native biocompatible Click chemistry approach to site-specifically modify TEM b-lactamase that adds new functionality....

Stoichiometric to catalytic reactivity of the aryl cycloaurated species with arylboronic acids: insight into the mechanism of gold-catalyzed oxidative C(sp2)–H arylation† †Electronic supplementary information (ESI) available: Detailed experimental procedures, analytical data. CCDC 1000469, 1007212 and 1019879. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c4sc02070g Click here for additional data file. Click here for additional data file.

Conformational properties of 1,4- and 1,5-substituted 1,2,3-triazole amino acids – building units for peptidic foldamers† †Electronic supplementary information (ESI) available: Tables on the RHF/3-21G conformers, NMR spectra and analysis. See DOI: 10.1039/c4ob02359e Click here for additional data file.

Transformable H-bonds and conformation in compressed glucose† †Electronic supplementary information (ESI) available: Detailed experimental data; detailed structural data. CCDC 1033994–1034008. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c4sc03588g Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file.

Photoresponsive immunomagnetic nanocarrier for capture and release of rare circulating tumor cells† †Electronic supplementary information (ESI) available: Detailed experimental procedures and materials; Fig. S1–S8 and Tables S1–S3. See DOI: 10.1039/c5sc01380a Click here for additional data file.